×
Well done. You've clicked the tower. This would actually achieve something if you had logged in first. Use the key for that. The name takes you home. This is where all the applicables sit. And you can't apply any changes to my site unless you are logged in.

Our policy is best summarized as "we don't care about _you_, we care about _them_", no emails, so no forgetting your password. You have no rights. It's like you don't even exist. If you publish material, I reserve the right to remove it, or use it myself.

Don't impersonate. Don't name someone involuntarily. You can lose everything if you cross the line, and no, I won't cancel your automatic payments first, so you'll have to do it the hard way. See how serious this sounds? That's how serious you're meant to take these.

Read the full thing here.
×
Register


Required. 150 characters or fewer. Letters, digits and @/./+/-/_ only.
  • Your password can’t be too similar to your other personal information.
  • Your password must contain at least 8 characters.
  • Your password can’t be a commonly used password.
  • Your password can’t be entirely numeric.

Enter the same password as before, for verification.
Login

Grow A Dic
Define A Word
Make Space
Set Task
Mark Post
Apply Votestyle
Create Votes
(From: saved spaces)
Exclude Votes
Apply Dic
Exclude Dic
Upload A File
Submit Email

Buy Advertising

Follow the form on the landing page to bid
for an uncensored self-regulated ad position.
Each word included bears the same ad


Login to enable post sorting. Buy/sell dictionaries which contain words which contain spaces (subreddits) to conglomerate posts and sell ads. Adverts pay users for each click and are auctioned off to the highest bidder. No clicks no credits. Posts do not archive, they stay active but can recirculate by editing to add new spaces (you can post to multiple spaces at once). We do not track your data, not even an email. Your content is yours, so you can input a Creative Commons on every post.

Click here to flash read.


<p>
Haematopoiesis relies on tightly controlled gene expression patterns as development proceeds through a series of progenitors. While the regulation of hematopoietic development has been well studied, the role of noncoding elements in this critical process is a developing field. In particular, the discovery of new regulators of lymphopoiesis could have important implications for our understanding of the adaptive immune system and disease. Here we elucidate how a noncoding element is capable of regulating a broadly expressed transcription factor, Ikaros, in a lymphoid lineage-specific manner, such that it imbues Ikaros with the ability to specify the lymphoid lineage over alternate fates. Deletion of the
<i>
Daedalus
</i>
locus, which is proximal to Ikaros, led to a severe reduction in early lymphoid progenitors, exerting control over the earliest fate decisions during lymphoid lineage commitment.
<i>
Daedalus
</i>
locus deletion led to alterations in Ikaros isoform expression and a significant reduction in Ikaros protein. The
<i>
Daedalus
</i>
locus may function through direct DNA interaction as Hi-C analysis demonstrated an interaction between the two loci. Finally, we identify an Ikaros-regulated erythroid-lymphoid checkpoint that is governed by
<i>
Daedalus
</i>
in a lymphoid-lineage-specific manner.
<i>
Daedalus
</i>
appears to act as a gatekeeper of Ikaros's broad lineage-specifying functions, selectively stabilizing Ikaros activity in the lymphoid lineage and permitting diversion to the erythroid fate in its absence. These findings represent a key illustration of how a transcription factor with broad lineage expression must work in concert with noncoding elements to orchestrate hematopoietic lineage commitment.
</p>

Click here to read this post out
ID: 329586; Unique Viewers: 0
Unique Voters: 0
Latest Change: June 6, 2022, 8:31 a.m. Changes:
Dictionaries:
Words:
Spaces:
Comments:
Newcom

Posts:

Total post views:

There are no posts.